Exact Sciences Stock (EXAS): Cologuard Plus Expansion Benefits

By Patricia Miller

Aug 01, 2025

3 min read

Exact Sciences broadens partnership with Humana, offering Cologuard Plus for 5.8 million members, enhancing access and driving growth.

#Exact Sciences Latest

Exact Sciences Corporation, known for its innovations in cancer diagnostics, is expanding its collaboration with Humana. Beginning August 2025, an estimated 5.8 million Medicare Advantage members will have access to its Cologuard Plus test.

The company initially introduced Cologuard Plus™ in March 2025, with expanded in‑network access via Humana beginning in August. This test, recently approved by the FDA, boasts a remarkable accuracy rate, with 95% sensitivity and 94% specificity, which means it reduces false positives by approximately 30–40 % compared to the original.

The new in-network coverage represents a pivotal moment in increasing access for eligible members, thus potentially driving colorectal cancer screenings more effectively. Analysts see this strategic move as a catalyst for growth, anticipating robust performance from Exact Sciences as it navigates through competitive waters in the healthcare market.

#What Investors Need to Know About Exact Sciences

  • Cologuard Plus “is covered by Medicare and has FDA approval.

  • The original Cologuard had ~92 % sensitivity / 87 % specificity, so the new version represents a meaningful improvement.

  • 2025 is expected to be a strong year with increased revenue from expanded access to its products.

  • The test's high sensitivity and specificity may enhance patient trust and screening rates.

  • Exact Sciences is positioned uniquely in the non-invasive cancer screening market.

  • The upcoming collaborations may lead to further partnerships with Medicare Advantage providers.

#Exact Sciences At A Glance

Exact Sciences is a biomedical company focused on cancer screening and diagnostic tests. Its flagship product, Cologuard, is the first and only stool DNA test approved by the FDA for colorectal cancer screening.

#Competitive Landscape

In the market for cancer diagnostics, Exact Sciences is up against other major players such as Guardant Health and Novartis. These companies also provide various testing options but face increasing competition in the non-invasive testing space. Guardant Health’s Shield test achieved ~83 % sensitivity in FDA approval, compared to Cologuard Plus’s 95 %, though ongoing competition is evolving.

#Near-Term Catalysts and Risks

The expansion of Cologuard Plus’s in-network availability could lead to a significant uptick in patient screenings and revenues, but competition remains a constant threat. This partnership may encourage similar agreements with other insurers, leading to market growth, although there’s a risk of regulatory changes impacting Medicare coverage.

#Trading EXAS Stock

When considering a position in Exact Sciences, you may want to assess both the growth potential and market competition. Watch for developments in its collaborations and new product introductions. Keeping an eye on quarterly earnings reports can provide valuable insights on how the company is performing relative to its projections and market expectations.

#FAQ

Why should I invest in a healthcare stock?

Investing in healthcare stocks can provide exposure to an essential industry with consistent demand. The sector often sees advancements that can lead to substantial returns as new treatments and technology emerge.

What makes Exact Sciences a compelling investment?

Exact Sciences has a strong presence in the cancer screening market, especially with its Cologuard test. As health awareness grows, demand for effective screening increases, positioning it well for future growth.

What should I look for in healthcare stocks?

Evaluate factors such as product pipeline, regulatory approvals, partnerships, and overall market positioning. Focus on companies with solid financials and innovation potential to enhance growth prospects.

Important Notice And Disclaimer

This article does not provide any financial advice and is not a recommendation to deal in any securities or product. Investments may fall in value and an investor may lose some or all of their investment. Past performance is not an indicator of future performance.